Z-DNA - Wikipedia
Z-DNA The Z-DNA structure. Proteopedia Z-DNA Z-DNA is one of the many possible double helical structures of DNA. It is a left-handed double helical structure in which the helix winds to …
Z-DNA in the genome: from structure to disease - PMC
In recent years, several non-canonical DNA structures including Z-DNA, G-quadruplexes, H-DNA, cruciform DNA, and i-motifs have been reported to form in genomic DNA and are closely …
Z-DNA at the crossroads: untangling its role in genome dynamics
Jan 27, 2025 · In this review we summarize the structure and function of Z-DNA within the genome while addressing the difficulties associated with identifying and investigating its role …
Z-DNA - an overview | ScienceDirect Topics
This review will focus on the location of Z-DNA in genomes as an example of how genomic and phylogenomic analyses can help to elucidate the functional role of a structure as well as its …
The Enigma of Z-DNA: A Twist in Biology - Simple Science
May 22, 2025 · In Z-DNA, the DNA helix winds to the left in a zigzag pattern instead of the right-handed B-DNA form. Z-DNA is thought to play a key role in transcription, but it is unclear …
Z-DNA: the long road to biological function - Nature
Jul 1, 2003 · Few laboratories worked on the biology of Z-DNA. However, the discovery that certain classes of proteins bound to Z-DNA with high affinity and great specificity indicated a …
Formation and biological implications of Z-DNA - PubMed
Z-DNA is a left-handed alternative DNA structure that forms at alternating purine-pyrimidine repeats, which are abundant in genomes. It is intrinsically unstable under physiological …
No Longer Controversial: A New Biological Role For Z-DNA In Cells
Oct 22, 2025 · The left-handed DNA was called Z-DNA, but was quickly dismissed as biologically relevant. Now, nearly fifty years later, an essential role for Z-DNA in cellular biology has been …
In these methods, –Z Btransition within Z-DNA-forming sequences (ZFSs), which are inserted in substantially longer DNA (usually, a plasmid) with various degrees of negative supercoiling, …
Z-DNA and Z-RNA in human disease - Communications Biology
Jan 7, 2019 · Alan Herbert discusses the properties of Z-DNA and Z-RNA, interactions with ADAR and other Z-binding proteins, and the role these elements play in disease.